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Important Information

Please note, we need you to ….
  • Read the important documents for this study
  • If you are interested, look at the dates that this study is being run (cohort visit planners) and  reply to our email (don’t re-register online) to let us know which cohort(s) you are available for
  • We will ring you to check your suitability and provide further information about the study
  • We will make you a screening appointment at NZCR Christchurch. You will need to attend at the scheduled time if you wish to take part in the study

Study Information

SGB-9768 is being developed for the treatment of complement-mediated disease. The complement system, also known as the complement cascade, is a part of the immune system that enhances (complements) immunity by providing a first line of defence to help fight against infections. However, excessive, or uncontrolled activation of the complement system can actually damage the body and result in diseases such as complement-mediated renal (kidney) disease.

SGB-9768 works by reducing the levels of protein called C3, which is involved in the activation of the complement pathway. The C3 protein plays an important role in the activation of the complement system, and a reduction in C3 is intended to help regulate the complement system and prevent any damage that would otherwise be caused by uncontrolled complement activity.  It is hoped that, by reducing the levels of C3, that SGB-9768 may inhibit the activation of this specific complement pathway and be an effective treatment for complement mediated diseases such as complement mediated renal disease.

It is an investigational drug because it has not been approved by MedSafe or other drug regulatory authorities.

This study (2023 FULL 19206) is being funded by Sangene Bio New Zealand Pty Ltd., and has been approved by the Health and Disability Ethics Committee.

Study Candidates

  • Healthy male or female aged 18 – 55 years
  • Are in good health
  • Have a BMI (Body Mass Index) between 18.5 kg/m2 – 32.0 kg/m2
  • Not currently taking any regular prescription medications for your health (e.g., anti-depressants)
  • May smoke or vape if on average 5 cigarettes or fewer per day  (or equivalent, including nicotine patches, gum or snuff etc.).

What is Involved?

Study Visits: 3 – night stay

Outpatient visits: 12 visits

Reimbursement: $5,500 (less tax)

Important Documents

Important documents to download and read

Pre-screening Form

Personal details

Please provide your name, email and phone number so we can contact you

Medical questions

Have you had any covid symptoms in the last two weeks or been in isolation?
Have you previously participated in a study with NZCR or any other organisation? Give details or leave blank if no
This study requires the use of contraception during the study. If you are in a hetereosexual relationship both partners must agree to use contraception (condoms for males | IUD, birth control or another approved form for females). Are you currently using 2 forms of contraception?
Participants in this study must be vaccinated against Nesseria meningitis (Menigococcal), Haemophilus influenza, and Streptococcus pneumonia. Are you happy to receive these vaccines if you're not yet vaccinated?
Do you have any history of medical conditions relating to:
Do you have any skin conditions or any tattoos on your abdomen, upper arm or thigh?
Have you donated blood or plasma in the last few months?
If unsure please note down what vaccines you have had in the last 6 months and when.
Do you have any history of allergies, asthma, hay fever, food allergies etc that you are aware of?
Have you taken any prescription, vitamins, supplements, pharmacy medication or over the counter medications in the last 14 days?
Just to inform you, that you come in for screening at risk. There is no payment for the screening visit, and you may not be offered a position on the study if the group fills up, or you may only be offered a position as a back-up. It is not guaranteed that you will get a full position on the study as it depends on your results as well. Are you comfortable with this?